Tesamorelin

FOR LABORATORY RESEARCH ONLY.

Product Specifications

• Product Name : Tesamorelin (Tesamorelin Acetate)
• Product Type : Synthetic GHRH Analogue (Growth Hormone-Releasing Hormone)
• Sequence Length : 44 Amino Acids
• Molecular Weight : ~5135.9 Da
• Purity : ≥99% (HPLC Verified)
• Solubility : Compatible with commonly used laboratory-grade aqueous solvents
• Form : Lyophilized Powder
• Storage : Store at -20°C, protected from light and moisture

Description

Chemical Identity & Characteristics

Tesamorelin is a 44-amino acid polypeptide sequence homologous to the N-terminal fragment of human GHRH. It is distinct from native GHRH due to a specific N-terminal modification: the addition of a trans-3-hexenoyl group.

In research applications, this hexenoyl moiety is investigated for its ability to provide steric shielding, potentially increasing resistance to enzymatic cleavage by dipeptidyl peptidase-4
(DPP-4) in experimental substrates. This structural modification is a key subject of study regarding peptide stability and pharmacodynamics compared to native GHRH sequences.

Molecular characteristics of Tesamorelin

Highlighting the N-terminal modification utilized in stability research.

 

The above illustration shows its peptide chain structure with highlighted functional groups and the compound name labeled underneath.

 

Analytical Validation & Certificate of Analysis (COA)

Priority Research places a strong emphasis on analytical transparency across all research materials. Our Tesamorelin is thoroughly tested to confirm both identity and purity.

 

• High-Performance Liquid Chromatography (HPLC): Evaluates peptide purity and helps detect possible impurities.
• Mass Spectrometry (MS): Confirms molecular weight (≈ 5135.9 Da) and verifies sequence identity.

A Certificate of Analysis (COA) may be provided upon request for each lot, giving researchers clear traceability and assurance that the material meets stringent specifications and has been properly characterized prior to shipment.

Storage, Stability & Handling (RUO)

This product is supplied as a sterile, lyophilized powder. To maintain stability and integrity:

• Storage: Vials should be stored at -20°C in a freezer.
• Protection: Keep vials away from direct light and moisture.
• Reconstitution: For laboratory preparation and analytical procedures only. Once reconstituted, the solution should be handled according to standard laboratory protocols for peptide stability, typically requiring refrigeration and use within a short timeframe.

This material is hygroscopic and should be allowed to reach room temperature before opening to prevent moisture absorption.

Research Context & Literature Overview

Tesamorelin has been the subject of extensive investigation in metabolic and neuroendocrine research. Scientific literature describes the compound as a GHRH agonist that binds to specific receptors on anterior pituitary somatotrophs.

Published studies report the following mechanistic observations:

Somatotropic Axis: Research indicates that the compound may stimulate the release of endogenous growth hormone (GH) in a pulsatile manner in test subjects, maintaining negative feedback loops via IGF-1.

Lipolytic Pathways: Preclinical models have explored the peptide’s selectivity for visceral adipose tissue modulation, investigating enzyme regulation such as lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL).

Hepatic Research: Studies have examined the effects of GHRH analogues on hepatic physiology, specifically regarding mitochondrial oxidation and de novo lipogenesis pathways in models of hepatic steatosis.

Neuroregeneration : Emerging research (e.g., Johns Hopkins University) is currently investigating the potential role of GHRH agonists in peripheral nerve regeneration and axonal outgrowth in injury models.

 

Research Use Only – Legal Disclaimer

All Priority Research products labeled as Research Use Only (RUO) are intended strictly for laboratory, investigational, and scientific research purposes. These materials are not approved by the FDA and are not intended for human or veterinary use, clinical applications, diagnostic procedures, or therapeutic treatment of any kind.

 By purchasing or using RUO materials, you acknowledge that they will be handled only within an appropriate research environment by qualified personnel who understand the risks, limitations, and regulatory requirements associated with experimental compounds. Products must not be administered to humans or animals, offered as therapeutic agents, or represented as safe or effective for any medical purpose.

 Use of these materials is entirely at your own risk. Priority Research assumes no liability for misuse, unsafe handling, improper application, or any regulatory or compliance issues arising from their use.